On his first day of official running in 2013, Lewis Hamilton crashed the new Mercedes.
Briton Hamilton sped over the gravel at the end of the back straight, hitting the tyre wall head-on.
A team spokesman said the cause was a braking problem.
“He managed to slow the car with the front brakes but was unable to avoid the barrier. Lewis is fine,” he said.
It is another blow to Mercedes, after Nico Rosberg’s debut running on Tuesday was cut short by an electrical fire.
“This is really annoying,” chairman Niki Lauda is quoted by Auto Motor und Sport.
“Yesterday we lost almost the whole day of testing, today again …”